Alkali salts of phenylethylbarbituric acid.



HEINRICH I-IOERLEIN, 0F VOHWINKEL, NEAR ELBERFELD, GERMANY, ASSIGNOR TO FARBENFABRIKEN VORILVI. FBIEDR. CORPORATION OF GERNIANY ALKALI SALTS BAYER &

00., OF ELBERFELD, (:rllilIRJVJIAIN'CZ A OF PHENYLETHYLBARBITURIC ACID.

No Drawing.

Specification of Letters Patent.

Patented Jan.28,1913.

Application filed September 11, 1912. Sprial No. 719,772;

To all whom it may concern Be it known that I, Hmmuorr Honnnnm, doctor of philosophy, German Empire, residing at Vohwinkel, near Elberfeld, Germany, have invented new and useful Improvements in Alkali Salts of Phenylethylbarbituric Acid, of which the following is a specification.

The prescnt application which is a coninued application from my Letters Patent lo. 1025872, filed September 0, 1911, relates pecifieally to the alkali salts of the phenyletihylbarbituric acid having most probably the formula:

CO-NX (i0 c'z s l l oo-nu (X meaning an alkali metal such as Na, K, Li) which have proved to be valuable hyp' notics'; an average dose being from 0.2 to 0.4; gram.

My new bodies are distinguished by a good solubility in water and are highly valuable for subcutaneous injections. '1. hey are after being dried crystalline white powders soluble in water, soluble with ditliculty in alcohol and insoluble in other. The process for their prodi'iction consists in treating the free acid with alkali metals or their hydroxids 0r carbonates.

In order to illustrate the new process chemist, citizen of the more tully the following example is'given, the parts being by weight 23 parts of sodiutn are dissolved in 350 parts of hot alcohol (free from water). To the resulting solution, at 0., 232 parts of phenylethylbaibituric acid are added. The sodium salt crystallizes is filter ed off, washed with alcohol and dried in "ca run at C. It is a white crystalline powder soluble in water, soluble with .diiliculty in alcohol, and insoluble in other.

I claim 1. The herein described alkali salts of ph enylethylbarbituric acid being white crystalline powders soluble in water; solubie with diiliculty in alcohol and insoluble in ether; being valuable hypnotics, substantially as describec.

'2. The herein described sodium salt of phenylethylbarbitnric acid being a white crystalline powder soluble in water, soluble with difiiculty in alcohol and insoluble in ether, being a valuable hypnotic, substantially as described.

1n testimony whereof I have hereunto set my hand in the presence of two subscribing witnesses.

HEINRICH HOERLEIN. [1 s.]

Witnesses HELEN Norma, ALBERT NUFER.

from the cooling liquid. It 

